We report on a novel microdevice to tune the curvature of a cell-adhering surface by controlling the air-pressure and micro-slit. Human aortic smooth muscle cells were cultured on demi-cylindrical concaves formed on a microdevice. Their shape-adapting behavior could be tracked when the groove direction was changed to the orthogonal direction. This microdevice demonstrated live observation of cells responding to dynamic changes of the anisotropic curvature of the adhering surface and could serve as a new platform to pursue mechanobiology on curved surfaces.

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中文翻译：

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气压驱动的可分离微型装置控制细胞培养表面的各向异性曲率。

我们报告了一种新型微型设备，通过控制气压和微缝来调整细胞粘附表面的曲率。人主动脉平滑肌细胞在微型装置上形成的半圆柱形凹部上培养。当凹槽方向改变为正交方向时，可以跟踪它们的形状适应行为。该微型装置展示了对细胞对粘附表面各向异性曲率动态变化的响应的实时观察，并且可以作为在曲面上研究机械生物学的新平台。

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