A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions.,G3: Genes, Genomes, Genetics

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A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions.
G3: Genes, Genomes, Genetics ( IF 2.1 ) Pub Date : 2020-09-01 , DOI: 10.1534/g3.120.401554
Dae-Kyum Kim _{1,

2,

3} , Jennifer J Knapp _{1,

2,

3} , Da Kuang _{1,

2,

3} , Aditya Chawla _{1,

2,

3} , Patricia Cassonnet _{4,

5,

6} , Hunsang Lee _{1,

2} , Dayag Sheykhkarimli _{1,

2,

3} , Payman Samavarchi-Tehrani ₃ , Hala Abdouni ₃ , Ashyad Rayhan _{1,

2,

3} , Roujia Li _{1,

2,

3} , Oxana Pogoutse _{1,

2,

3} , Étienne Coyaud ₇ , Sylvie van der Werf _{4,

5,

6} , Caroline Demeret _{4,

5,

6} , Anne-Claude Gingras _{2,

3} , Mikko Taipale _{1,

2,

8} , Brian Raught ₉ , Yves Jacob _{5,

6,

10} , Frederick P Roth _{2,

3,

11,

12}

Affiliation

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Unité de Génétique Moléculaire des Virus à ARN, Département Virologie, Institut Pasteur, Paris, France.
UMR3569, Centre National de la Recherche Scientifique, Paris, France.
Université de Paris, Paris, France.
Univ. Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France.
Molecular Architecture of Life Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.
Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Unité de Génétique Moléculaire des Virus à ARN, Département Virologie, Institut Pasteur, Paris, France
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.

The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

中文翻译：

全面、灵活的 SARS-CoV-2 编码区域集合。

世界正面临由 SARS-CoV-2 冠状病毒引起的新冠肺炎 (COVID-19) 全球大流行。在这里，我们描述了克隆到 Gateway 兼容的入门载体中的 SARS-CoV-2 密码子优化编码序列集合，这些序列能够快速转移到各种表达和标签载体中。该集合可免费获取。我们希望这种 SARS-CoV-2 资源的广泛使用将使许多后续分子研究能够更好地了解病毒生命周期以及如何阻止它。

更新日期：2020-09-02

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