The Hippo pathway undertakes a pivotal role in organ size control and the process of physiology and pathology in tissue. Its downstream effectors YAP1 and TAZ receive upstream stimuli and exert transcription activity to produce biological output. Studies have demonstrated that the Hippo pathway contributes to maintenance of cardiac homeostasis and occurrence of cardiac disease. And these cardiac biological events are affected by crosstalk among Hippo-YAP1/TAZ, Wnt/β-catenin, Bone morphogenetic protein (BMP) and G-protein-coupled receptor (GPCR) signaling, which provides new insights into the Hippo pathway in heart. This review delineates the interaction among Hippo, Wnt, BMP and GPCR pathways and discusses the effects of these pathways in cardiac biology.

中文翻译：

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Hippo-YAP1/TAZ 通路的作用及其在心脏生物学中的串扰。

Hippo 通路在器官大小控制以及组织的生理学和病理学过程中发挥着关键作用。其下游效应子 YAP1 和 TAZ 接受上游刺激并发挥转录活性以产生生物输出。研究表明，Hippo 通路有助于维持心脏稳态和心脏病的发生。并且这些心脏生物学事件受到 Hippo-YAP1/TAZ、Wnt/β-catenin、骨形态发生蛋白 (BMP) 和 G 蛋白偶联受体 (GPCR) 信号之间串扰的影响，这为心脏中的 Hippo 通路提供了新的见解. 本综述描述了 Hippo、Wnt、BMP 和 GPCR 通路之间的相互作用，并讨论了这些通路在心脏生物学中的作用。