The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing all around the world and it may become the primary cause of terminal liver disease in adults and children in the next few decades. However, the pathogenesis of NAFLD is complex, and the Food and Drug Administration (FDA) has not approved any drugs for its treatment. Kupffer cells are the key cells regulating immunity in the liver, and the effect of their unique polarization on NAFLD has received increasing attention. Kupffer cells mainly reside in the lumen of hepatic sinusoids and account for 80% to 90% of colonized macrophages in the human body. They are phagocytic cells with the capacity for self-renewal that rarely migrate from their niche in the liver, and play a crucial role in regulating and maintaining homeostasis. Upon liver damage, Kupffer cells will be activated, releasing a good deal of inflammatory cytokines and chemokines. This review summarizes the multiple roles of Kupffer cells in the pathogenesis of NAFLD, the role of infiltrating macrophages in the pathogenesis of NAFLD is also briefly discussed, and aims to provide a theoretical basis for designing an NAFLD treatment strategy with Kupffer cells as the therapeutic target.

中文翻译：

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非酒精性脂肪肝中的库普弗细胞：朋友还是敌人？

非酒精性脂肪性肝病 (NAFLD) 的患病率在世界范围内不断增加，并可能在未来几十年成为成人和儿童终末期肝病的主要原因。然而，NAFLD的发病机制复杂，美国食品药品监督管理局（FDA）尚未批准任何药物用于其治疗。枯否细胞是肝脏中调节免疫的关键细胞，其独特的极化对 NAFLD 的影响越来越受到关注。库普弗细胞主要存在于肝窦腔内，占人体内定植巨噬细胞的 80% 至 90%。它们是具有自我更新能力的吞噬细胞，很少从肝脏中的生态位迁移，并在调节和维持体内平衡方面发挥关键作用。肝脏受损时，库普弗细胞会被激活，释放大量炎性细胞因子和趋化因子。本文综述了库普弗细胞在NAFLD发病机制中的多重作用，并对浸润巨噬细胞在NAFLD发病机制中的作用进行了简要讨论，旨在为设计以库普弗细胞为治疗靶点的NAFLD治疗策略提供理论依据。 .