Although cholesterol is an essential and necessary component for biological systems; inappropriate accumulation of cholesterol in blood vessels and intracellular territory is also detrimental to living things. On one hand, cholesterol is the acting precursor of many metabolic regulators, a component of the structural veracity and scaffold fluidity of biomembranes, an insulator of electrical transmission in nerves and many more; on the other hand, its deposition in blood vessels induces atherosclerotic plaque and cardiovascular complications with the consequences of heart attack and stroke. It is also an emerging fact that cholesterol is a prelate in the cell nucleus for cell proliferation and any oddity in this venture may be the cause of tumorigenesis. Hence, cholesterol homeostasis is a very crucial element in issues of health management. Cholesterol is now a global target for maintaining quality health, particularly to control the two giants of the present world health tragedy: atherosclerosis and carcinoma, which appear to be the two facets of dysfunctional cholesterol homeostasis.

中文翻译：

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动脉粥样硬化和癌：胆固醇功能稳态失调的两个方面。

尽管胆固醇是生物系统必不可少的组成部分；胆固醇在血管和细胞内区域的不适当积累也不利于生物。一方面，胆固醇是许多代谢调节剂的起作用的前体，是生物膜的结构准确性和支架流动性的组成部分，是神经电传递的绝缘体等等。另一方面，其在血管中的沉积会引起动脉粥样硬化斑块和心血管并发症，并伴有心脏病和中风的后果。一个新出现的事实是胆固醇是细胞核中用于细胞增殖的主要产物，这种冒险行为可能是导致肿瘤发生的原因。因此，胆固醇稳态是健康管理中非常关键的因素。