Abstract

The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally included in this meta-analysis. We noticed that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms were significantly associated with the risk of osteoporosis in Caucasians. Moreover, BsmI rs1544410 and FokI rs10735810 polymorphisms were significantly associated with the risk of osteoporosis in Asians. In conclusion, this meta-analysis demonstrates that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Caucasians, while BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Asians.

摘要

作者进行了这项荟萃分析，以稳健地估计VDR中多态性之间的关系通过整合先前工作的结果，基因和骨质疏松症的风险。对Medline、Embase、万方、VIP和CNKI进行了全面检索，最终纳入了73项遗传关联研究。我们注意到 ApaI rs7975232、BsmI rs1544410 和 TaqI rs731236 多态性与白种人骨质疏松症的风险显着相关。此外，BsmI rs1544410 和 FokI rs10735810 多态性与亚洲人骨质疏松症的风险显着相关。总之，该荟萃分析表明，ApaI rs7975232、BsmI rs1544410 和 TaqI rs731236 多态性可能影响白种人骨质疏松症的风险，而 BsmI rs1544410 和 TaqI rs731236 多态性可能影响亚洲人骨质疏松症的风险。