Mismatch negativity (MMN) amplitude has been widely shown to be diminished in schizophrenia and, more recently, in other psychotic disorders. Although there is considerable evidence linking MMN reduction to cognitive and functional deficits in schizophrenia, there is little evidence of associations with specific psychotic symptoms. Further, it is unclear if MMN reductions relate to specific symptoms, cognitive, and functional deficits transdiagnostically across different psychotic disorders. The present study examines MMN amplitude in a large cohort of cases diagnosed with psychotic disorders including schizophrenia and schizoaffective disorder (N = 116); bipolar disorder and major depressive disorder (N = 75); and other psychotic disorders (N = 25), as well as individuals with no psychotic disorder diagnoses (N = 248). Furthermore, we examined the association of MMN with symptoms, cognitive functioning, and real-world functioning to determine whether these relationships differ by diagnosis. Results showed that MMN amplitude was reduced in cases overall compared to never-psychotic individuals, with no differences between psychotic disorders. Furthermore, there were transdiagnostic associations of reduced duration MMN (MMN-D) with worse auditory hallucinations (r = .14) and disorganization (r = .14), frequency MMN (MMN-F) with real-word functioning (r = .20) and episodic memory (r = -.22), and both components with executive functioning (MMN-D: r = -.17; MMN-F: r = -.15). Our findings relating MMN reductions with cognitive and real-world functioning replicate earlier research in schizophrenia and extend these relationships to other psychotic disorders. Furthermore, our correlations with MMN-D are consistent with computational modeling research and theoretical proposals that view MMN reduction, cognitive dysfunction, and psychotic symptoms as reflecting underlying predictive coding deficits. However, differences in relationships with MMN-F suggest that additional work is warranted on this topic. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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失配消极性与精神病症状的关联以及跨精神病性障碍的跨诊断功能。


错配负性（MMN）幅度已被广泛证明在精神分裂症以及最近的其他精神障碍中减少。尽管有大量证据表明 MMN 减少与精神分裂症的认知和功能缺陷有关，但几乎没有证据表明 MMN 减少与特定的精神病症状有关。此外，尚不清楚 MMN 降低是否与不同精神障碍的特定症状、认知和功能缺陷跨诊断相关。本研究检查了一大群诊断为精神障碍（包括精神分裂症和分裂情感障碍）病例的 MMN 振幅（N = 116）；双相情感障碍和重度抑郁症（N = 75）；和其他精神障碍 (N = 25)，以及没有精神障碍诊断的个体 (N = 248)。此外，我们检查了 MMN 与症状、认知功能和现实世界功能的关联，以确定这些关系是否因诊断而异。结果显示，与非精神病患者相比，总体病例的 MMN 振幅降低，并且精神病之间没有差异。此外，MMN持续时间缩短（MMN-D）与更严重的幻听（r = .14）和混乱（r = .14）、频率MMN（MMN-F）与真实单词功能（r = .14）之间存在跨诊断关联。 20）和情景记忆（r = -.22），以及具有执行功能的两个组件（MMN-D：r = -.17；MMN-F：r = -.15）。我们将 MMN 减少与认知和现实世界功能联系起来的研究结果复制了早期对精神分裂症的研究，并将这些关系扩展到其他精神障碍。 此外，我们与 MMN-D 的相关性与计算模型研究和理论建议一致，这些研究和理论建议认为 MMN 减少、认知功能障碍和精神病症状反映了潜在的预测编码缺陷。然而，与 MMN-F 关系的差异表明，在这个主题上需要进行额外的工作。 （PsycInfo 数据库记录 (c) 2020 APA，保留所有权利）。