The lack of stringent regulations regarding raw materials for herbal supplements used for medicinal purposes has been a constant challenge in the industry. Ginkgo biloba L. leaf extracts attract consumers because of the supposed positive effect on mental performance and memory. Supplements are produced using dried leaf materials and standardized leaf extracts such as EGb 761. Adulteration of Ginkgo biloba L. plants and extracts are becoming more and more common practice due to economically driven motivation from increasing demand in the market and the high cost of raw materials and production. Reinforcement in quality control (QC) to avoid adulterations is necessary to ensure the efficacy of the supplements. In this study, liquid chromatography-high-resolution mass spectrometry (LC-HRMS) was used with principal component analysis (PCA) as an unsupervised exploratory method to analyze, identify, and evaluate the adulterated Ginkgo biloba L. plant materials and dried leaf extracts using the PCA scores and loadings obtained and compound identification.

对于药用草药补充剂的原材料缺乏严格的规定一直是该行业面临的一个持续挑战。银杏叶提取物因其对精神表现和记忆力的积极作用而吸引了消费者。使用干燥的叶子材料和标准化的叶子提取物（例如 EGb 761）生产补充剂。由于市场需求不断增长和原材料成本高昂所带来的经济驱动力，银杏叶植物和提取物的掺假正变得越来越普遍。和生产。为了确保补充剂的功效，有必要加强质量控制（QC）以避免掺假。在本研究中，采用液相色谱-高分辨率质谱（LC-HRMS）和主成分分析（PCA）作为无监督探索方法来分析、鉴定和评估掺假银杏植物材料和干叶提取物使用获得的 PCA 分数和负载以及化合物鉴定。