Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood–brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have been explored by scientists for overcoming the BBB from disruption of the BBB to targeted delivery of nanoparticles (NPs) and cells and immunotherapy. In this review, different promising brain drug delivery strategies including disruption of tight junctions in the BBB, enhanced transcellular transport by peptide-based delivery, local delivery strategies, NP delivery, and cell-based delivery have been fully discussed.

中文翻译：

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克服神经退行性疾病和脑肿瘤中的血脑屏障。

药物输送是治疗中枢神经系统疾病的主要挑战之一。大脑需要保护免受有害物质的侵害，这是通过毛细血管网络，即所谓的血脑屏障（BBB）来完成的。这种保护罩还阻止治疗剂输送到大脑并限制治疗的有效性。因此，科学家们探索了各种克服 BBB 的策略，从破坏 BBB 到靶向递送纳米颗粒 (NP) 和细胞以及免疫疗法。在这篇综述中，充分讨论了不同有前途的脑药物递送策略，包括破坏血脑屏障中的紧密连接、通过基于肽的递送增强跨细胞转运、局部递送策略、NP递送和基于细胞的递送。