Humoral immunity is key to protection for nearly all licensed vaccines. Yet, the design of vaccines has been more difficult for some of our most deadly killers (e.g. HIV, influenza, Dengue virus, etc.), likely due to our incomplete understanding of the precise immunological mechanisms associated with protection. Humoral immunity is governed both by B-cells and their bi-functional secreted antibodies, all of which have a unique capacity to evolve during an immune response. Current OMIC technologies capture individual features of the humoral immune response, providing a glimpse into humoral components (Fab/Fc/B-cell-omic), but fail to provide a wholistic view of the humoral response as a collective functional arm. Here, we dissect current OMIC strategies reviewing experimental and computational approaches, that if integrated could provide a true systems-level view of the humoral immune response.

中文翻译：

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剖析抗体-OME：过去、现在和未来。

体液免疫是保护几乎所有许可疫苗的关键。然而，对于我们的一些最致命的杀手（例如 HIV、流感、登革热病毒等）来说，疫苗的设计更加困难，这可能是由于我们对与保护相关的精确免疫机制的理解不完整。体液免疫由 B 细胞及其分泌的双功能抗体控制，所有这些抗体在免疫反应过程中都具有独特的进化能力。当前的 OMIC 技术捕获了体液免疫反应的个体特征，提供了对体液成分（Fab/Fc/B 细胞组学）的一瞥，但未能提供将体液反应作为一个集体功能臂的整体视图。在这里，我们剖析了当前的 OMIC 策略，回顾了实验和计算方法，