Much more serious than the previous severe acute respiratory syndrome (SARS) coronavirus (CoV) outbreaks, the novel SARS-CoV-2 infection has spread speedily, affecting 213 countries and causing ~17,300,000 million cases and ~672,000 (~+1500/day) deaths globally (as of July 31^th, 2020). The potentially fatal COVID-19, caused by air droplets and airborne as the main transmission modes, clearly induces a spectrum of respiratory clinical manifestations, but it also affects the immune, gastrointestinal, hematological, nervous and renal systems. The dramatic scale of disorders and complications arise from the inadequacy of current treatments, absence of a vaccine and specific anti-COVID-19 drugs to suppress viral replication, inflammation and additional pathogenic conditions. This highlights the importance of understanding the SARS-CoV-2 mechanisms of actions, and the urgent need of prospecting for new or alternative treatment options. The main objective of the present review is to discuss the challenging issue relative to the clinical utility of plants-derived polyphenols in fighting viral infections. Not only is the strong capacity of polyphenols highlighted in magnifying health benefits, but also the underlying mechanisms are stressed. Finally, emphasis is placed on the potential ability of polyphenols to combat SARS-CoV-2 infection via the regulation of its molecular targets of human cellular binding and replication, as well as through the resulting host inflammation, oxidative stress and signalling pathways.

中文翻译：

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多酚植物疗法能否成为预防和治疗 2019 新型冠状病毒病 (COVID-19) 的有力方法？


新型 SARS-CoV-2 感染比之前的严重急性呼吸综合征 (SARS) 冠状病毒 (CoV) 爆发严重得多，传播迅速，影响了 213 个国家，造成约 17,300,0 亿例病例和约 672,000 例（约+1500 例/天）全球死亡人数（截至 2020 年 7 月 31^日）。潜在致命的COVID-19以空气飞沫和空气传播为主要传播方式，明显诱发一系列呼吸道临床表现，但也会影响免疫、胃肠道、血液、神经和肾脏系统。由于当前治疗方法不足、缺乏疫苗和特定抗 COVID-19 药物来抑制病毒复制、炎症和其他致病条件，造成了巨大的疾病和并发症。这凸显了了解 SARS-CoV-2 作用机制的重要性，以及探索新的或替代治疗方案的迫切需要。本综述的主要目的是讨论与植物源多酚在对抗病毒感染方面的临床应用相关的挑战性问题。不仅强调了多酚在放大健康益处方面的强大能力，而且还强调了其潜在机制。最后，重点强调多酚通过调节其与人类细胞结合和复制的分子靶标以及由此产生的宿主炎症、氧化应激和信号通路来对抗 SARS-CoV-2 感染的潜在能力。