Purpose

The goal of this study was to develop chemotherapeutic drug-loaded photoactivable stealth polymer-coated silica based- mesoporous titania nanoplatforms for enhanced antitumor activity.

Methods

Both in vitro and in vivo models of solvothermal treated photoactivable nanoplatforms were evaluated for efficient chemo-photothermal activity. A versatile nanocomposite that combined silica based- mesoporous titania nanocarriers (S-MTN) with the promising photoactivable agent, graphene oxide (G) modified with a stealth polymer (P) was fabricated to deliver chemotherapeutic agent, imatinib (I), (referred as S-MTN@IG-P) for near-infrared (NIR)-triggered drug delivery and enhanced chemo-photothermal therapy.

Results

The fabricated S-MTN@IG-P nanoplatform showed higher drug loading (~20%) and increased drug release (~60%) in response to light in acidic condition (pH 5.0). As prepared nanoplatform significantly converted NIR light into thermal energy (43.2°C) to produce reactive oxygen species (ROS). The pronounced cytotoxic effect was seen in both colon cancer cells (HCT-116 and HT-29) that was mediated through the chemotherapeutic effect of imatinib and the photothermal and ROS generation effects of graphene oxide. In vivo study also showed that S-MTN@IG-P could significantly accumulate into the tumor area and suppress the tumor growth under NIR irradiation without any biocompatibility issues.

Conclusion

Cumulatively, the above results showed promising effects of S-MTN@IG-P for effective chemo-phototherapy of colon cancer.

中文翻译：

---

隐形聚合物涂层的氧化石墨烯修饰的中孔二氧化钛纳米平台用于体内化学光动力学癌症治疗。

目的

这项研究的目的是开发化学治疗药物负载的光活化隐形聚合物涂层的二氧化硅基介孔二氧化钛纳米平台，以增强抗肿瘤活性。

方法

二者在体外和体内溶剂热处理的可光活化的纳米平台的模型有效化学-光热活性进行了评价。制备了一种多功能的纳米复合材料，将二氧化硅基介孔二氧化钛纳米载体（S-MTN）与有前途的光活化剂氧化石墨烯（G）修饰为隐形聚合物（P）组合而成，可递送化学治疗剂伊马替尼（I）（ S-MTN @ IG-P）用于近红外（NIR）触发的药物输送和增强的化学光热疗法。

结果

制备的S-MTN @ IG-P纳米平台在酸性条件下（pH 5.0）对光有较高的载药量（〜20％）和增加的药物释放（〜60％）。所制备的纳米平台将NIR光显着转化为热能（43.2°C），从而产生活性氧（ROS）。在两个结肠癌细胞（HCT-116和HT-29）中均观察到明显的细胞毒性作用，这是通过伊马替尼的化学治疗作用以及氧化石墨烯的光热和ROS产生作用介导的。体内研究还表明，S-MTN @ IG-P可以在NIR照射下显着积聚到肿瘤区域并抑制肿瘤生长，而没有任何生物相容性问题。

结论

累积地，以上结果表明S-MTN @ IG-P对结肠癌的有效化学光疗具有可观的效果。