The human gut microbiome intimately complements the human genome and gut microbial factors directly influence health and disease. Here we outline how the gut microbiota uniquely contributes to cancer etiology by processing products of human drug and endobiotic metabolism. We formally propose that the reactions performed by the gut microbiota should be classified as “Phase IV xenobiotic and endobiotic metabolism.” Finally, we discuss new data on the control of cancer by the inhibition of gut microbial phase IV enzymes responsible for tumor initiation and progression.

中文翻译：

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肠道菌群通过药物和内生素的“IV 相代谢”影响癌症病因

人类肠道微生物组与人类基因组密切互补，肠道微生物因素直接影响健康和疾病。在这里，我们概述了肠道微生物群如何通过处理人类药物和内生素代谢产物对癌症病因学做出独特贡献。我们正式提议将肠道微生物群进行的反应归类为“第四阶段异生素和内生素代谢”。最后，我们讨论了通过抑制负责肿瘤发生和发展的肠道微生物 IV 期酶来控制癌症的新数据。