Mangrove sediment-associated bacteria are of significantly important in the field of medicine and pharmaceuticals as new promising sources of biologically active pharmacophores due to the extreme conditions, such as high salt concentration and soil anoxia. The sediment bacteria associated with Acanthus ilicifolius and Avicennia officinalis collected from the Mangalavanam mangrove ecosystem of the Kerala State of India were evaluated using various in vitro models for the assessment of their pharmacological properties. The bacteria exhibiting significant antioxidant and antimicrobial activities were isolated, identified, and characterized by the integrated microbiological, biochemical, and 16S rRNA sequencing. Among the varied bacteria isolated from mangrove sediments, Bacillus amyloliquefaciens MBMS5 (GenBank accession number MK765025) exhibited significant antimicrobial activities against various pathogenic bacteria, such as Aeromonas caviae , Vibrio parahemolyticus , and methicillin-resistant Staphylococcus aureus . The extracellular extracts of B. amyloliquefaciens MBMS5 exhibited potential antioxidant activity against free radical species coupled with anti-inflammatory property as displayed by the attenuation activity against pro-inflammatory 5-lipoxygenase.

中文翻译：

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一些红树林沉积物相关芽孢杆菌的药理特性

由于高盐浓度和土壤缺氧等极端条件，红树林沉积物相关细菌作为生物活性药效团的新的有希望的来源在医学和制药领域具有重要意义。从印度喀拉拉邦 Mangalavanam 红树林生态系统收集的与 Acanthus ilicifolius 和 Avicennia officinalis 相关的沉积物细菌使用各种体外模型进行评估，以评估其药理特性。通过综合微生物学、生化和 16S rRNA 测序分离、鉴定和表征具有显着抗氧化和抗菌活性的细菌。在从红树林沉积物中分离出的各种细菌中，解淀粉芽孢杆菌 MBMS5（GenBank 登录号 MK765025）对各种病原菌表现出显着的抗菌活性，如气单胞菌、副溶血性弧菌和耐甲氧西林金黄色葡萄球菌。B. amyloliquefaciens MBMS5 的细胞外提取物对自由基种类表现出潜在的抗氧化活性以及抗炎特性，如对促炎 5-脂氧合酶的减弱活性所显示的。