In this work, a dual-mode stimulus chip with a built-in high voltage generator was proposed to offer a broad-range current or voltage stimulus patterns for biomedical applications. With an on-chip and built-in high voltage generator, this stimulus chip could generate the required high voltage supply without additional supply voltage. With a nearly 20 V operating voltage, the overstress and reliability issues of the stimulus circuits were thoroughly considered and carefully addressed in this work. This stimulus system only requires an area of 0.22 mm ² per single channel and is fully on-chip implemented without any additional external components. The dual-mode stimulus chip was fabricated in a 0.25-μm 2.5V/5V/12V CMOS (complementary metal-oxide-semiconductor) process, which can generate the biphasic current or voltage stimulus pulses. The current level of stimulus is up to 5 mA, and the voltage level of stimulus can be up to 10 V. Moreover, this chip has been successfully applied to stimulate a guinea pig in an animal experiment. The proposed dual-mode stimulus system has been verified in electrical tests and also demonstrated its stimulation function in animal experiments.

中文翻译：

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用于生物医学应用的内置高压发生器的双模刺激芯片设计。

在这项工作中，提出了一种内置高压发生器的双模式刺激芯片，为生物医学应用提供宽范围的电流或电压刺激模式。通过片上和内置高压发生器，该激励芯片无需额外的电源电压即可生成所需的高压电源。在接近 20 V 的工作电压下，这项工作充分考虑并仔细解决了激励电路的过应力和可靠性问题。这个刺激系统只需要 0.22 mm ²的面积 每个单通道，并且完全在片上实现，无需任何额外的外部组件。双模激励芯片采用 0.25-μm 2.5V/5V/12V CMOS（互补金属氧化物半导体）工艺制造，可产生双相电流或电压激励脉冲。电流刺激可达5mA，刺激电压可达10V。此外，该芯片已成功应用于对豚鼠的动物实验刺激。所提出的双模式刺激系统已在电气测试中得到验证，并在动物实验中证明了其刺激功能。