Ultrashort peptides (USPs), composed of three to seven amino acids, can self-assemble into nanofibers in pure water. Here, using hydrodynamic focusing and a solvent exchange method on a microfluidic setup, we convert these nanofibers into globular nanoparticles with excellent dimensional control and polydispersity. Thanks to USP nanocarriers’ structure, different drugs can be loaded. We used Curcumin as a model drug to evaluate the performance of USP nanocarriers as a novel drug delivery vehicle. These nanoparticles can efficiently cross the cell membrane and possess nonlinear optical properties. Therefore, we envisage USP nanoparticles as promising future theranostic nanocarriers.

中文翻译：

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通过微流体辅助快速溶剂交换的超短肽治疗纳米粒子。

由三到七个氨基酸组成的超短肽 (USP) 可以在纯水中自组装成纳米纤维。在这里，我们在微流体装置上使用流体动力学聚焦和溶剂交换方法，将这些纳米纤维转化为具有出色尺寸控制和多分散性的球状纳米粒子。由于 USP 纳米载体的结构，可以装载不同的药物。我们使用姜黄素作为模型药物来评估 USP 纳米载体作为新型药物递送载体的性能。这些纳米粒子可以有效地穿过细胞膜并具有非线性光学特性。因此，我们将 USP 纳米颗粒视为有前途的未来治疗纳米载体。