The comorbidity of depression and addiction has become a serious public health issue, and the relationship between these two disorders and their potential mechanisms has attracted extensive attention. Numerous studies have suggested that depression and addiction share common mechanisms and anatomical pathways. The nucleus accumbens (NAc) has long been considered a key brain region for regulating many behaviors, especially those related to depression and addiction. In this review article, we focus on the association between addiction and depression, highlighting the potential mediating role of the NAc in this comorbidity via the regulation of changes in the neural circuits and molecular signaling. To clarify the mechanisms underlying this association, we summarize evidence from overlapping reward neurocircuitry, the resemblance of cellular and molecular mechanisms, and common treatments. Understanding the interplay between these disorders should help guide clinical comorbidity prevention and the search for a new target for comorbidity treatment.

中文翻译：

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伏隔核：抑郁症和成瘾合并症的共同目标。

抑郁症和成瘾的合并症已成为严重的公共卫生问题，这两种疾病之间的关系及其潜在机制已引起广泛关注。大量研究表明，抑郁和成瘾具有共同的机制和解剖学途径。伏伏核（NAc）长期以来一直被认为是调节许多行为的关键大脑区域，尤其是那些与抑郁和成瘾有关的行为。在这篇综述文章中，我们着重于成瘾与抑郁之间的关联，强调了通过调节神经回路和分子信号传导，NAc在这种合并症中的潜在介导作用。为了弄清这种关联的机制，我们总结了重叠奖励神经回路的证据，细胞和分子机制的相似之处，以及常见的治疗方法。了解这些疾病之间的相互作用应有助于指导临床合并症的预防和寻找合并症治疗的新目标。