1-Fluoroindan-1-carboxyic acid (FICA) derivatives containing a monosubstituted benzene ring (1b–e) were synthesized as their methyl esters and their potential as chiral derivatizing agents (CDAs) were assessed by both ¹⁹F- and ¹H-NMR spectroscopy. Introduction of a substituent at the 4-position in the benzene ring caused a 1.2–2 fold increase in Δδ_F values when compared with that of FICA. This increase was investigated using a correlation model for ¹⁹F-NMR and by the order of the stability of the synperiplanar (sp) and antiperiplanar (ap) conformers of the (R,S) and (S,S) diastereomers from the Gibbs’ free energy at 298.15 K.

合成了含有一个单取代苯环（1b – e）的1-氟丹丹-1-羧酸（FICA）衍生物作为它们的甲酯，并通过¹⁹ F-和¹ H-NMR评估了它们作为手性衍生剂（CDA）的潜力光谱学。在苯环的4位上的取代基的引入导致了一个Δδ1.2-2倍增加_˚F当与FICA的比较的值。使用¹⁹ F-NMR的相关性模型和（R的上平面（sp）和反上平面（ap）构象异构体的稳定性顺序研究了这种增加，S）和（S，S）非对映体的吉布斯自由能在298.15 K。