The dosages of drugs in newborn infants are small. Small dose necessitate consideration of the loss of drug when administered via feeding tube. In this study, we conducted a tube administration test for seven kinds of antiepileptic drugs and two kinds of potassium supplements using a neonatal feeding tube and investigated the drug loss using the collection rate. We also studied the differences in collection rates among different dosage forms and drugs to determine the more suitable dosage forms and drugs. We investigated three dosage forms: powder, fine granules or dry syrup (powdery form) drugs, powdery form drugs that have been pulverized (pulverized powdery forms), and pulverized tablets. Additionally, we investigated two potassium supplements to determine which was more suitable: potassium L-aspartate and potassium gluconate. For topiramate, only the powdery form caused tube obstructions; the collection rates of the pulverized powdery form and pulverized tablets were > 90%. All antiepileptic drugs other than topiramate that were tested had collection rates of about > 90%. Considering stability and pharmacokinetics, the more suitable dosage form for topiramate is pulverized tablets, whereas the more suitable dosage form for other antiepileptic drugs is powdery form. Collection rate of potassium gluconate was higher than that of potassium L-aspartate. The current study, which indicates that potassium gluconate powdery form is the more suitable drug, presents the more suitable dosage form and drug for administration via feeding tube to newborn infants. These results show that it is essential to evaluate passage through the tube using the collection rate.

新生婴儿的药物剂量很小。小剂量需要考虑通过给药时药物的损失喂食管。在这项研究中，我们使用新生儿饲管对7种抗癫痫药和2种钾补充剂进行了输液管试验，并使用收集率调查了药物流失的情况。我们还研究了不同剂型和药物之间收集率的差异，以确定更合适的剂型和药物。我们研究了三种剂型：粉剂，细粒或干糖浆（粉状剂）药物，已粉化的粉状剂（粉状粉剂）和粉状片剂。此外，我们调查了两种钾补充剂以确定哪种更合适：L-天门冬氨酸钾和葡萄糖酸钾。对于托吡酯，只有粉末状会引起管阻塞。粉状和粉状片剂的收集率> 90％。除托吡酯外，所有抗癫痫药物的收集率均> 90％。考虑到稳定性和药代动力学，托吡酯更适合的剂型是粉状片剂，而其他抗癫痫药更适合的剂型是粉状。葡萄糖酸钾的收集率高于L-天冬氨酸钾。当前的研究表明，葡萄糖酸钾粉状形式是更合适的药物，它提供了更合适的剂型和给药药物 托吡酯更适合的剂型是粉状片剂，而其他抗癫痫药更适合的剂型是粉状剂型。葡萄糖酸钾的收集率高于L-天冬氨酸钾。当前的研究表明，葡萄糖酸钾粉状形式是更合适的药物，它提供了更合适的剂型和给药药物 托吡酯更适合的剂型是粉状片剂，而其他抗癫痫药更适合的剂型是粉状剂型。葡萄糖酸钾的收集率高于L-天冬氨酸钾。当前的研究表明，葡萄糖酸钾粉状形式是更合适的药物，它提供了更合适的剂型和给药药物通过给婴儿喂食管。这些结果表明，使用收集率评估通过试管的通道至关重要。