Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection “hot-spots,” medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure–activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.

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中文翻译：

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从吹牛中分离得到的抗疟烯丙基邻苯二酚的构效关系。

疟疾仍然是世界范围内严重的健康问题。在东南亚，疟疾感染的一种“热点”的药用植物如荜betle传统上一直用于治疗疟疾，和allylpyrocatechol（1），的构成P. betle，已显示展示抗疟疾活动。在这项研究中，我们验证了1不仅通过腹膜内（ip ）施用，而且还通过口服（po）施用表现出体内抗疟疾活性。此外，某些类似物1 合成并分析了结构-活性关系，以揭示有效活性的关键子结构。

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