The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease.

中文翻译：

---

从损害响应框架的角度看 COVID-19 的发病机制。


由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的 2019 冠状病毒病 (COVID-19) 大流行给医学界带来了重大挑战。 COVID-19 是一种全新的疾病，具有不同的临床表现，很难用单一的致病原理来协调。在这里，我们解释了微生物发病机制的“损害反应框架”（DRF）的灵活范式如何将 COVID-19 的各种表现组织成一个综合体，该综合体解释了弱势群体易感性的差异以及不同表现的不同表现。 COVID-19 疾病。通过关注宿主损伤机制，特别是免疫介导的损伤机制，DRF 提供了一个了解 COVID-19 发病机制并考虑潜在疗法如何改变这种疾病结果的视角。