Aim and Objective: Sleep bruxism is a complicated disease, and its cause remains controversial. If the etiology of bruxism is resolved, the treatment can be adjusted to the prevailing aetiological factor. Thus, the aim of this study was to evaluate the oxidative stress level and serum prolidase activity in patients with sleep bruxism.

Materials and Methods: Seventy healthy subjects and 51 patients with sleep bruxism were included in this study, and blood samples from all patients were collected. Serum samples were analyzed for total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and prolidase activity.

Results: The prolidase, TOS, and OSI levels were significantly higher in patients with bruxism than in the healthy controls (p = 0.001, p = 0.001, p = 0.001, respectively). The TAS level was significantly lower in bruxism patients than in healthy controls (p = 0.003).

Conclusion: The increased TOS, OSI, and prolidase levels and decreased TAS levels could be assumed to result in oxidative injury in patients with sleep bruxism. However, the study could not determine whether oxidative imbalance and increased serum prolidase levels could be a cause or a result of bruxism.

目的与目的：睡眠磨牙症是一种复杂的疾病，其病因仍有争议。如果磨牙症的病因得到解决，治疗可以根据主要的病因进行调整。因此，本研究的目的是评估睡眠磨牙症患者的氧化应激水平和血清脯氨酸酶活性。

材料与方法：本研究纳入70名健康受试者和51名睡眠磨牙症患者，采集所有患者的血样。分析血清样品的总抗氧化状态 (TAS)、总氧化状态 (TOS)、氧化应激指数 (OSI) 和脯氨酸酶活性。

结果：磨牙症患者的脯氨酸酶、TOS 和 OSI 水平显着高于健康对照组（分别为 p = 0.001、p = 0.001、p = 0.001）。磨牙症患者的 TAS 水平显着低于健康对照组（p = 0.003）。

结论：可以假设 TOS、OSI 和脯氨酸酶水平升高以及 TAS 水平降低会导致睡眠磨牙症患者的氧化损伤。然而，该研究无法确定氧化失衡和血清脯氨酸酶水平升高是否是磨牙症的原因或结果。