Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model.

中文翻译：

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基于脂多糖的神经炎症会诱发小胶质细胞极化吗？

当局部和/或全身给药时，脂多糖（LPS）是一种有效的免疫原。LPS的外围免疫可能会导致神经系统疾病的进展，因为已发现神经炎症与多巴胺能变性之间存在密切的联系。黑质的存活和神经元死亡之间的转换可能与M1（神经毒性）和M2（神经保护）小胶质细胞表型有关。在这篇综述中，我们介绍了在基于LPS的鼠模型中确定的有关小胶质细胞作用，生物标记以及天然或合成免疫调节剂的最新发现。