Humans have internal circadian clocks that ensure important physiological functions occur at specific times of the day. These molecular clocks are regulated at the genomic level and exist in most cells of the body. Multiple circadian resetting cues have been identified, including light, temperature and food. Recently, oxygen has been identified as a resetting cue and emerging science indicates that this occurs through interactions at the cellular level between the circadian transcription-translation feedback loop and the hypoxia inducible pathway (HIF; subject of the 2019 Nobel Prize in Physiology or Medicine). This review will cover recently identified relationships between HIF and proteins of the circadian clock. Interactions between the circadian clock and hypoxia could have wide reaching implications for human diseases and understanding the molecular mechanisms regulating these overlapping pathways may open up new strategies for drug discovery.

中文翻译：

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气喘吁吁，时间time：HIF和昼夜节律之间的相互作用。

人类具有内部生物钟，以确保重要的生理功能在一天的特定时间发生。这些分子钟在基因组水平上受到调节，并存在于人体的大多数细胞中。已经确定了多种昼夜节律线索，包括光照，温度和食物。最近，氧气已被确定为一种重置提示，新兴科学表明氧气是通过昼夜节律翻译-翻译反馈回路与缺氧诱导途径之间的细胞水平相互作用而发生的（HIF; 2019年诺贝尔生理学或医学奖的主题） 。这篇综述将涵盖最近发现的HIF和昼夜节律蛋白之间的关系。