Background: Cancer is considered as the main public health problem and the second leading cause of morbidity and mortality worldwide. Numerous environmental-lifestyle related risk factors account for around one-third of cancer deaths. Recently, the key role of lncRNAs has been widely investigated in a variety of disorders, including cancer. The lncRNA GHET1 has been considered as an essential oncogenic lncRNA in many types of human cancers. Clinical investigations indicated that expression of lncRNA GHET1 is correlated with clinicopathological characteristics in cancer. This metaanalysis investigated the correlation between the lncRNA GHET1 expression and clinicopathological features in different types of cancers.

Materials and Methods: Comprehensive literature searches in PubMed, Scopus, and Web of Knowledge were conducted up to April 11, 2019. Sixteen studies were included in this meta-analysis. All statistical analyses were conducted using Stata software, version 12.0.

Results: The pooled OR and 95%CIs of the sixteen relevant studies showed that over expression of lncRNA GHET1 was associated with tumor-size ≥5 cm (OR= 2.51, 95% CI: 1.89-3.33, p=0.00, I2=38.30%), positive lymph node metastasis (OR= 2.83, 95% CI: 1.78-4.52, p=0.00, I2=45.60%), advanced tumor stage (OR= 3.92, 95% CI: 2.97-5.19, p=0.00, I2=0.00%), positive distant metastasis (OR= 5.74, 95% CI: 2.58-12.77, p=0.00, I2=0.00%), advanced tumor status (OR= 2.97, 95% CI: 1.40- 6.29, p=0.01, I2=34.70%), and positive vascular invasion (OR= 2.69, 95% CI: 1.61-4.50, p=0.00, I2=29.20%).

Conclusion: Taken together, the current study demonstrated that overexpression of lncRNA GHET1 is significantly associated with clinicopathological features in human cancers. Our results suggested that lncRNA GHET1 can be utilized as a prognostic biomarker in human cancer.

背景：癌症被认为是全球主要的公共卫生问题，也是发病率和死亡率的第二大主要原因。与环境生活方式相关的众多风险因素约占癌症死亡人数的三分之一。最近，lncRNA的关键作用已在包括癌症在内的多种疾病中得到广泛研究。lncRNA GHET1被认为是许多类型人类癌症中必不可少的致癌lncRNA。临床研究表明，lncRNA GHET1的表达与癌症的临床病理特征有关。这项荟萃分析调查了lncRNA GHET1表达与不同类型癌症的临床病理特征之间的相关性。

材料和方法：截至2019年4月11日，在PubMed，Scopus和Web of Knowledge中进行了全面的文献检索。该荟萃分析包括16项研究。所有统计分析均使用Stata软件12.0版进行。

结果：十六项相关研究的总OR和95％CIs显示，lncRNA GHET1的过度表达与肿瘤大小≥5cm有关（OR = 2.51，95％CI：1.89-3.33，p = 0.00，I2 = 38.30 ％），阳性淋巴结转移（OR = 2.83，95％CI：1.78-4.52，p = 0.00，I2 = 45.60％），晚期肿瘤分期（OR = 3.92，95％CI：2.97-5.19，p = 0.00， I2 = 0.00％），远处转移阳性（OR = 5.74，95％CI：2.58-12.77，p = 0.00，I2 = 0.00％），晚期肿瘤状态（OR = 2.97，95％CI：1.40-6.29，p = 0.01，I2 = 34.70％）和阳性血管侵犯（OR = 2.69，95％CI：1.61-4.50，p = 0.00，I2 = 29.20％）。

结论：综上所述，当前的研究表明，lncRNA GHET1的过表达与人类癌症的临床病理特征显着相关。我们的结果表明，lncRNA GHET1可以用作人类癌症的预后生物标志物。