HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.,Antimicrobial Agents and Chemotherapy

当前位置： X-MOL 学术 › Antimicrob. Agents Chemother. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2020-09-21 , DOI: 10.1128/aac.00782-20
Chloé Loiseau _{1,

2} , Daniela Brites _{1,

2} , Miriam Reinhard _{1,

2} , Kathrin Zürcher ₃ , Sonia Borrell _{1,

2} , Marie Ballif ₃ , Lukas Fenner ₃ , Helen Cox ₄ , Liliana K Rutaihwa _{1,

2,

5} , Robert J Wilkinson _{6,

7,

8} , Marcel Yotebieng ₉ , E Jane Carter ₁₀ , Alash'le Abimiku ₁₁ , Olivier Marcy _{12,

13} , Eduardo Gotuzzo ₁₄ , Anchalee Avihingsanon ₁₅ , Nicola Zetola ₁₆ , Basra Doulla _{17,

18} , Erik C Böttger _{19,

20} , Matthias Egger _{3,

21} , Sebastien Gagneux _{2,

22}

Affiliation

Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa.
Ifakara Health Institute, Bagamoyo, Tanzania.
Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa.
Department of Infectious Diseases, Imperial College London, London, United Kingdom.
Francis Crick Institute, London, United Kingdom.
Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Medicine, Moi University School of Medicine, and Moi Teaching and Referral Hospital, Eldoret, Kenya.
Institute of Human Virology, Abuja, Nigeria.
Centre de Prise en Charge de Recherche et de Formation, Yopougon, Abidjan, Côte d'Ivoire.
Bordeaux Population Health Research Center, Inserm U1219, University of Bordeaux, Bordeaux, France.
TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
The HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Centre and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Central Tuberculosis Reference Laboratory, Dar es Salaam, Tanzania.
National Tuberculosis and Leprosy Programme, Dar es Salaam, Tanzania.
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Swiss National Center for Mycobacteria, Zurich, Switzerland.
Centre for Infectious Disease Epidemiology and Research, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Swiss Tropical and Public Health Institute, Basel, Switzerland

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

中文翻译：

HIV 合并感染与耐利福平结核分枝杆菌中的低适应性 rpoB 变体有关。

我们分析了从 9 个结核病高负担国家的 HIV 合并感染和 HIV 阴性结核病患者中收集的312 个结核分枝杆菌分离株的耐药基因组。我们发现，从 HIV 共感染患者中分离的利福平耐药结核分枝杆菌菌株在rpoB中携带更多的耐药突变，这些突变与在没有药物的情况下低适应性相关，这表明这些低适应性rpoB变体可以在宿主免疫力降低的背景。

更新日期：2020-09-21

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>