Candida auris has been shown to have a high risk of skin colonization in hospitalized patients, possibly contributing to nosocomial spread. In a guinea pig skin model, animals were evaluated for clinical appearance, tissue fungal burden, histology, and pharmacokinetics. Oral dosing with 10 mg/kg ibrexafungerp (IBX) reduced the severity of lesions and significantly reduced the C. auris fungal burden in infected animals compared with untreated controls. This indicates promise for use of IBX in controlling skin infection and colonization of hospitalized patients.

中文翻译：

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在体内豚鼠皮肤感染模型中，Ibrexafungerp（SCY-078）对耳假丝酵母的功效。

住院念珠菌已被证明具有很高的皮肤定植风险，可能导致医院内传播。在豚鼠皮肤模型中，对动物的临床外观，组织真菌负荷，组织学和药代动力学进行了评估。用10mg / kg的ibrexafungerp（IBX）口服给药降低病变的严重程度和显著降低C.耳与未处理的对照相比，在受感染的动物的真菌负担。这表明使用IBX来控制住院患者的皮肤感染和定植有希望。