The increase of CD8 + T lymphocytes in the perivascular spaces of patients with HIV encephalopathy has been reported in some studies. CD8 + T lymphocyte encephalitis was first described in 2013 and then a few other similar cases were published. We proposed to analyze the clinical, MR imaging, and histopathology findings of CD8 + T lymphocyte encephalitis. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyzes protocol using the PubMed, Scopus, Lilacs, and IBECS databases up to February 3, 2018. Seven articles were included, two case series and five case reports. A total of 19 individuals were evaluated. MRI showed alterations in the white matter signal in all cases. Histopathology showed a predominance of CD8 + T lymphocytes. The findings described so far may resemble the inflammatory immune reconstitution syndrome. New studies on the subject are needed in an attempt to characterize the differences between these two entities.

中文翻译：

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CD8 + T 淋巴细胞脑炎：系统评价。

一些研究报道了HIV脑病患者血管周围间隙CD8+T淋巴细胞的增加。CD8+T淋巴细胞脑炎于2013年首次被描述，随后又发表了一些其他类似病例。我们建议分析 CD8 + T 淋巴细胞脑炎的临床、磁共振成像和组织病理学结果。截至 2018 年 2 月 3 日，根据系统评价和荟萃分析协议的首选报告项目，使用 PubMed、Scopus、Lilacs 和 IBECS 数据库进行了系统评价。其中包括 7 篇文章、2 个病例系列和 5 个病例报告。共有 19 人接受了评估。MRI 显示所有病例的白质信号均发生变化。组织病理学显示CD8+T淋巴细胞占优势。迄今为止描述的发现可能类似于炎症免疫重建综合征。需要对此主题进行新的研究，以试图描述这两个实体之间的差异。