Pre-exposure prophylaxis (PrEP) has been shown to be an effective approach to prevent human immunodeficiency virus (HIV) infections; however, implementation of the service remains challenging. This global bibliometric analysis aims to describe the current trends in HIV research prevention through PrEP to reveal the potential gaps of knowledge and to put forward recommendations for future research. A bibliometric analysis was conducted through Web of Science from 1990 to 2017. Exploratory factor analysis was also employed to find research domains emerging from the abstracts' contents. Latent Dirichlet allocation, which is a topic modeling algorithm, was utilized to perform text mining and determine relationships among text documents. A total of 4852 papers regarding HIV PrEP research were retrieved. The number of papers and their impact has significantly increased. Preventing sexual transmissions, improving access, and quality of health-care services for current users, as well as men who have sex with men, pregnant women and children, were the research domains most related to PrEP. We found a data gap in research regarding sex workers, potential side effects of PrEP, and misjudgment toward PrEP users. Despite the growth in research about HIV PrEP, there exist barriers to scaling up the implementation of PrEP worldwide and for such intervention to reach its fWull potential. International research collaboration efforts to investigate the potential safety concerns of PrEP and develop strategies to eliminate social misjudgment against PrEP users are warranted. Addressing these knowledge gaps might facilitate the development of effective global implementation strategies for PrEP in the future.

中文翻译：

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HIV研究中的暴露前预防：潜在的狄利克雷分配分析（GAPRESEARCH）。

暴露前预防（PrEP）已被证明是预防人类免疫缺陷病毒（HIV）感染的有效方法。但是，服务的实施仍然具有挑战性。这项全球文献计量分析旨在描述通过PrEP进行的HIV研究预防的当前趋势，以揭示潜在的知识差距，并为以后的研究提出建议。从1990年至2017年，通过Web of Science进行了文献计量分析。还利用探索性因素分析来查找摘要内容中出现的研究领域。潜在的Dirichlet分配是一种主题建模算法，用于执行文本挖掘和确定文本文档之间的关系。总共检索了4852篇有关HIV PrEP研究的论文。论文数量及其影响已大大增加。预防性传播，改善当前使用者以及与男人，孕妇和儿童发生性关系的男人的保健服务的质量和服务质量是与PrEP最相关的研究领域。我们发现有关性工作者，PrEP的潜在副作用以及对PrEP用户的误判的研究存在数据缺口。尽管有关HIV PrEP的研究有所增加，但在全球范围内扩大PrEP的实施以及使此类干预发挥其全部潜力仍存在障碍。必须开展国际研究合作，以调查PrEP的潜在安全问题，并制定消除对PrEP用户的社会误判的策略。