Interleukin (IL)-6 is a pleotropic cytokine with various physiological and pathophysiological functions in different cells and tissues. In cells residing within white adipose tissue, several and sometimes conflicting IL-6 actions have been described in the development of obesity-associated derangements of glucose metabolism. Herein, we aim to summarize opposing findings and discuss recent evidence that IL-6 signaling in adipose tissue is regulated in a depot and cell specific manner.

中文翻译：

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肥胖组织中IL-6在肥胖引起的葡萄糖代谢失调中的争议作用。

白介素（IL）-6是一种多效性细胞因子，在不同的细胞和组织中具有多种生理和病理生理功能。在存在于白色脂肪组织中的细胞中，在与肥胖相关的葡萄糖代谢紊乱的发展过程中，已经描述了几种甚至有时相互冲突的IL-6作用。在本文中，我们旨在总结相反的发现，并讨论脂肪组织中IL-6信号传导以贮库和细胞特异性方式调节的最新证据。