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Understanding the Role of Inflammasomes in Rheumatoid Arthritis.
Inflammation ( IF 4.5 ) Pub Date : 2020-07-25 , DOI: 10.1007/s10753-020-01301-1
Rashita Makkar 1 , Tapan Behl 1 , Simona Bungau 2 , Arun Kumar 1 , Sandeep Arora 1
Affiliation  

Inflammasomes are the molecular pathways that activate upon conditions of infection or stress and trigger the activation and maturation of inflammatory cytokines. Immune reactions in conjugation with inflammatory processes play a pivotal role in developing innumerable diseases. An over reactive immune system fabricates many allergic and hypersensitive reactions in response to autoantibodies activated against modified self-epitopes and similar molecules. Rheumatoid arthritis (RA) is a complex autoimmune inflammatory disorder commencing with inflammation in small joints like hands, knees, and wrist eventually entrapping larger joints such as spine. The formation of autoantibodies called rheumatoid factor (RF) and citrullinated proteins against immunoglobulin G symbolizes autoimmune nature of the disease. The presence of autoantibodies embarks principal diagnostic hallmark of the disease. With the advancement of technology, the therapeutic approach is also advancing. A new era of molecules, namely inflammasomes, are activated upon infection or in response to stress and trigger the activation of various proinflammatory cytokines such interleukins which engage in the defense mechanism of the innate immunity. Robust linking among the activity of dysregulated inflammasomes and the heritable acquired inflammatory diseases and disorders emphasizes the significance of this pathway in altering the immune responses. The current review highlights the functioning of inflammasomes and their possible role in disease dysregulation.



中文翻译:

了解炎症小体在类风湿性关节炎中的作用。

炎性体是在感染或压力条件下激活并触发炎性细胞因子的激活和成熟的分子途径。与炎症过程结合的免疫反应在无数疾病的发展中起着关键作用。过度反应的免疫系统会制造许多过敏和超敏反应,以响应针对修饰的自身表位和类似分子激活的自身抗体。类风湿性关节炎 (RA) 是一种复杂的自身免疫性炎症性疾病,始于手、膝和腕等小关节的炎症,最终累及脊柱等较大的关节。称为类风湿因子 (RF) 的自身抗体和针对免疫球蛋白 G 的瓜氨酸化蛋白的形成象征着该疾病的自身免疫性质。自身抗体的存在是该疾病的主要诊断标志。随着科技的进步,治疗方法也在进步。一个新的分子时代,即炎症小体,在感染或响应压力时被激活,并触发各种促炎细胞因子的激活,例如参与先天免疫防御机制的白介素。失调的炎症小体的活性与可遗传的获得性炎症疾病和病症之间的牢固联系强调了该途径在改变免疫反应中的重要性。目前的综述强调了炎症小体的功能及其在疾病失调中的可能作用。一个新的分子时代,即炎症小体,在感染或响应压力时被激活,并触发各种促炎细胞因子的激活,例如参与先天免疫防御机制的白介素。失调的炎症小体的活性与可遗传的获得性炎症疾病和病症之间的牢固联系强调了该途径在改变免疫反应中的重要性。目前的综述强调了炎症小体的功能及其在疾病失调中的可能作用。一个新的分子时代,即炎症小体,在感染或响应压力时被激活,并触发各种促炎细胞因子的激活,例如参与先天免疫防御机制的白介素。失调的炎症小体的活性与可遗传的获得性炎症疾病和病症之间的牢固联系强调了该途径在改变免疫反应中的重要性。目前的综述强调了炎症小体的功能及其在疾病失调中的可能作用。失调的炎症小体的活性与可遗传的获得性炎症疾病和病症之间的牢固联系强调了该途径在改变免疫反应中的重要性。目前的综述强调了炎症小体的功能及其在疾病失调中的可能作用。失调的炎症小体的活性与可遗传的获得性炎症疾病和病症之间的牢固联系强调了该途径在改变免疫反应中的重要性。目前的综述强调了炎症小体的功能及其在疾病失调中的可能作用。

更新日期:2020-07-25
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