Background:Qing-Dai (QD) treatment of patients with ulcerative colitis (UC) sometimes causes pulmonary arterial hypertension (PAH). However, the relationship of QD treatment to pulmonary arterial systolic pressure (PASP) in patients with UC has not been clarified.

Methods and Results:The 27 patients with UC who were screened for PAH by transthoracic echocardiography (TTE) and underwent repeat TTE at 1 year were analyzed in this prospective observational study. Mean age was 44.0 years old, and median follow-up duration was 392. During the follow-up, 21 patients continued QD treatment (continuous group) and 6 patients discontinued the treatment (discontinuous group). In all patients, no significant difference in PASP levels between baseline and at follow-up was observed (21.4 vs. 21.3 mmHg, P=0.802). Furthermore, the mean PASP of patients in the continuous group did not differ from baseline to follow-up (21.4 mmHg to 22.6 mmHg, P=0.212); however, in the discontinuous group mean PASP was significantly decreased (21.5 mmHg to 16.8 mmHg, P=0.005). Moreover, changes in PASP from baseline to follow-up differed between the continuous and discontinuous groups (+1.1 mmHg vs. −4.7 mmHg, P=0.004). In addition, multivariable analyses revealed that only the duration of oral QD at baseline affected the increase of PASP.

Conclusions:In patients with UC, QD treatment may have an undesirable association with an increase in PASP.

背景：青黛（QD）治疗溃疡性结肠炎（UC）有时会导致肺动脉高压（PAH）。然而，UC患者QD治疗与肺动脉收缩压（PASP）的关系尚不清楚。

方法和结果：在这项前瞻性观察研究中，分析了27例经胸腔超声心动图（TTE）筛查PAH并在1年后再次行TTE的UC患者。平均年龄为44.0岁，中位随访时间为392。在随访期间，有21例患者继续进行QD治疗（连续组），有6例患者中断了治疗（连续组）。在所有患者中，基线和随访之间的PASP水平均无显着差异（21.4 vs. 21.3 mmHg，P = 0.802）。此外，连续组患者的平均PASP从基线到随访无差异（21.4 mmHg至22.6 mmHg，P = 0.212）；然而，在不连续组中，平均PASP显着降低（21.5 mmHg至16.8 mmHg，P = 0.005）。此外，从基线到随访，PASP的变化在连续组和不连续组之间有所不同（+1.1 mmHg对-4.7 mmHg，P = 0.004）。此外，多变量分析显示，基线时口服QD的持续时间会影响PASP的增加。

结论：在UC患者中，QD治疗可能与PASP增加有关。