Tendon is a collagenous tissue to connect bone and muscle. Healing of damaged/injured tendon is the primary clinical challenge in musculoskeletal regeneration because they often react poorly to treatment. Tissue engineering (a triad strategy of scaffolds, cells and growth factors) may have the potential to improve the quality of tendon tissue healing under such impaired situations. Tendon tissue engineering aims to synthesize graft alternatives to repair the injured tendon. Biological scaffolds derived from decellularized tissue may be a better option as their biomechanical properties are similar to the native tissue. This review is designed to provide background information on the current challenges in curing torn/worn out the tendon and the clinical relevance of decellularized scaffolds for such applications.

肌腱是连接骨骼和肌肉的胶原组织。受损/受伤肌腱的愈合是肌肉骨骼再生的主要临床挑战，因为它们通常对治疗反应不佳。组织工程（支架、细胞和生长因子的三联策略）可能有可能在这种受损情况下提高肌腱组织的愈合质量。肌腱组织工程旨在合成移植替代品来修复受伤的肌腱。源自脱细胞组织的生物支架可能是更好的选择，因为它们的生物力学特性与天然组织相似。本综述旨在提供有关当前在治疗撕裂/磨损的肌腱方面面临的挑战以及脱细胞支架在此类应用中的临床相关性的背景信息。