当前位置: X-MOL 学术Annu. Rev. Microbiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Implications of the Evolutionary Trajectory of Centromeres in the Fungal Kingdom.
Annual Review of Microbiology ( IF 8.5 ) Pub Date : 2020-09-09 , DOI: 10.1146/annurev-micro-011720-122512
Krishnendu Guin 1 , Lakshmi Sreekumar 1 , Kaustuv Sanyal 1
Affiliation  

Chromosome segregation during the cell cycle is an evolutionarily conserved, fundamental biological process. Dynamic interaction between spindle microtubules and the kinetochore complex that assembles on centromere DNA is required for faithful chromosome segregation. The first artificial minichromosome was constructed by cloning the centromere DNA of the budding yeast Saccharomyces cerevisiae. Since then, centromeres have been identified in >60 fungal species. The DNA sequence and organization of the sequence elements are highly diverse across these fungal centromeres. In this article, we provide a comprehensive view of the evolution of fungal centromeres. Studies of this process facilitated the identification of factors influencing centromere specification, maintenance, and propagation through many generations. Additionally, we discuss the unique features and plasticity of centromeric chromatin and the involvement of centromeres in karyotype evolution. Finally, we discuss the implications of recurrent loss of RNA interference (RNAi) and/or heterochromatin components on the trajectory of the evolution of fungal centromeres and propose the centromere structure of the last common ancestor of three major fungal phyla—Ascomycota, Basidiomycota, and Mucoromycota.

中文翻译:


真菌王国中着丝粒进化轨迹的意义。

细胞周期中的染色体分离是进化上保守的基本生物学过程。忠实的染色体分离需要纺锤体微管和在着丝粒DNA上组装的动粒复合体之间的动态相互作用。通过克隆出芽酵母酿酒酵母的着丝粒DNA,构建了第一个人工微型染色体。从那时起,已经在> 60种真菌中鉴定出着丝粒。在这些真菌着丝粒中,DNA序列和序列元件的组织高度不同。在本文中,我们提供了真菌着丝粒进化的全面视图。对这一过程的研究有助于确定影响着丝粒规格,维持和传代的因素。此外,我们讨论着丝粒染色质的独特特征和可塑性以及着丝粒在核型进化中的参与。最后,我们讨论了RNA干扰(RNAi)和/或异染色质成分的反复丢失对真菌着丝粒进化轨迹的影响,并提出了三种主要真菌门-子囊菌的最后一个共同祖先的着丝粒结构,

更新日期:2020-09-10
down
wechat
bug