Using photoelectron elliptical dichroism (PEELD) to determine real-time variation of enantiomeric excess.,Chirality

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Using photoelectron elliptical dichroism (PEELD) to determine real-time variation of enantiomeric excess.
Chirality ( IF 2.8 ) Pub Date : 2020-07-22 , DOI: 10.1002/chir.23267
Antoine Comby ₁ , Caoimhe M M Bond ₂ , Etienne Bloch ₁ , Dominique Descamps ₁ , Baptiste Fabre ₁ , Stephane Petit ₁ , Yann Mairesse ₁ , Jason B Greenwood ₂ , Valerie Blanchet ₁

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In this work, the photoionization of chiral molecules by an elliptically polarized, high repetition rate, femtosecond laser is probed. The resulting 3D photoelectron angular distribution shows a strong forward–backward asymmetry, which is highly dependent not only on the molecular structure but also on the ellipticity of the laser pulse. By continuously varying the laser ellipticity, we can observe molecular and enantiomer changes in real time at a previously unseen speed and precision. The technique allows enantiomeric excess of a pure compound to be measured with a 5% precision within 3 s, and a 10‐min acquisition yields a precision of 0.4%. The isomers camphor and fenchone can be easily distinguished, unlike with conventional mass spectrometry. Preliminary results for the pharmaceutically interesting ibuprofen are also given, showing the capability of photoionization as a means of distinguishing larger molecular systems.

中文翻译：

使用光电子椭圆二色性（PEELD）确定对映体过量的实时变化。

在这项工作中，通过椭圆偏振，高重复率的飞秒激光探测了手性分子的光电离。产生的3D光电子角度分布显示出强烈的前后不对称性，这不仅高度依赖于分子结构，而且高度依赖于激光脉冲的椭圆率。通过连续改变激光椭圆率，我们可以以前所未有的速度和精度实时观察分子和对映体的变化。该技术允许在3 s内以5％的精度测量纯化合物的对映异构体过量，并且10分钟的采集可产生0.4％的精度。与常规质谱法不同，樟脑和芬琴酮的异构体易于区分。还给出了药用布洛芬的初步结果，

更新日期：2020-07-22

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