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Metabolic Activity of Anthocyanin Extracts Loaded into Non-ionic Niosomes in Diet-Induced Obese Mice.
Pharmaceutical Research ( IF 3.5 ) Pub Date : 2020-07-22 , DOI: 10.1007/s11095-020-02883-z Diana Colorado 1 , Maritza Fernandez 2 , Jahir Orozco 2 , Yasmin Lopera 3 , Diana Lorena Muñoz 4 , Sergio Acín 1, 4 , Norman Balcazar 1, 4
中文翻译:
在饮食诱导的肥胖小鼠中,加载到非离子型脂质体中的花色苷提取物的代谢活性。
更新日期:2020-07-22
Pharmaceutical Research ( IF 3.5 ) Pub Date : 2020-07-22 , DOI: 10.1007/s11095-020-02883-z Diana Colorado 1 , Maritza Fernandez 2 , Jahir Orozco 2 , Yasmin Lopera 3 , Diana Lorena Muñoz 4 , Sergio Acín 1, 4 , Norman Balcazar 1, 4
Affiliation
Purpose
Anthocyanins (ACNs) are polyphenols that might reduce pathological processes associated with type 2 diabetes mellitus and other chronic diseases, but their bioavailability is still controversial. In this study, the metabolic activity of oral delivery of ACN-loaded niosomes was investigated and evaluated in a diet-induced obesity (DIO) mice model.Methods
ACNs extracted from Vaccinium Meridionale by the supercritical fluid extraction method were loaded in niosomes. The niosomal formulation was physically characterized and further administrated in drinking water to obese, insulin resistant mouse. We evaluated the effect of ACN loaded niosomes on hyperglycemia, glucose and insulin intolerance and insulin blood levels in C57BL/6 J mice fed with a high-fat diet.Results
The ACN-loaded particles were moderately monodisperse, showed a negative surface charge and 57% encapsulation efficiency. The ACN-loaded niosomes ameliorated the insulin resistance and glucose intolerance in the DIO mice model. Additionally, they reduced animal weight and plasma insulin, glucose, leptin and total cholesterol levels in obese mice.Conclusion
ACN-loaded niosomes administration, as a functional drink, had a beneficial effect on the reversal of metabolic abnormalities associated with obesity.中文翻译:
在饮食诱导的肥胖小鼠中,加载到非离子型脂质体中的花色苷提取物的代谢活性。