Purpose

Anthocyanins (ACNs) are polyphenols that might reduce pathological processes associated with type 2 diabetes mellitus and other chronic diseases, but their bioavailability is still controversial. In this study, the metabolic activity of oral delivery of ACN-loaded niosomes was investigated and evaluated in a diet-induced obesity (DIO) mice model.

Methods

ACNs extracted from Vaccinium Meridionale by the supercritical fluid extraction method were loaded in niosomes. The niosomal formulation was physically characterized and further administrated in drinking water to obese, insulin resistant mouse. We evaluated the effect of ACN loaded niosomes on hyperglycemia, glucose and insulin intolerance and insulin blood levels in C57BL/6 J mice fed with a high-fat diet.

Results

The ACN-loaded particles were moderately monodisperse, showed a negative surface charge and 57% encapsulation efficiency. The ACN-loaded niosomes ameliorated the insulin resistance and glucose intolerance in the DIO mice model. Additionally, they reduced animal weight and plasma insulin, glucose, leptin and total cholesterol levels in obese mice.

Conclusion

ACN-loaded niosomes administration, as a functional drink, had a beneficial effect on the reversal of metabolic abnormalities associated with obesity.

中文翻译：

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在饮食诱导的肥胖小鼠中，加载到非离子型脂质体中的花色苷提取物的代谢活性。

目的

花青素（ACN）是多酚，可能减少与2型糖尿病和其他慢性疾病有关的病理过程，但其生物利用度仍存在争议。在这项研究中，在饮食诱发的肥胖症（DIO）小鼠模型中研究并评估了口服ACN负载的脂质体口服递送的代谢活性。

方法

通过超临界流体萃取法从越橘越橘提取的乙腈装在脂质体中。对该体配方进行了物理表征，并在饮用水中进一步给予肥胖，胰岛素抵抗的小鼠。我们评估了ACN负载的脂质体对高脂饮食喂养的C57BL / 6 J小鼠的高血糖，葡萄糖和胰岛素耐受性以及胰岛素血液水平的影响。

结果

载有ACN的颗粒呈中等程度的单分散，显示负表面电荷和57％的包封效率。载有ACN的脂质体改善了DIO小鼠模型的胰岛素抵抗和葡萄糖耐受不良。此外，它们减少了肥胖小鼠的动物体重和血浆胰岛素，葡萄糖，瘦素和总胆固醇水平。

结论

载有ACN的脂质体作为功能性饮料，对逆转与肥胖有关的代谢异常具有有益作用。