The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and their implications for improving cancer therapy and propose that the approaches that have been taken to understand the autophagy-apoptosis connection to enhance cancer drug action can serve as a model for the kinds of information that should be developed to understand how autophagy controls other biological processes as well.

中文翻译：

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自噬和细胞凋亡之间的串扰：机制和治疗意义。

宏观自噬的细胞再循环过程是将细胞材料通过称为自噬体的双层膜囊泡传递至溶酶体的机制，与细胞程序性死亡途径（特别是细胞凋亡）密切相关。在本文中，我将讨论一些改善癌症治疗的潜在机制及其含义，并建议为了解自噬-细胞凋亡连接以增强癌症药物作用而采取的方法可作为应提供的各种信息的模型了解自噬如何控制其他生物过程。