The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory and protective/barrier functions necessary to manage the chronic exposures to environmental, mechanical, and oxidative stressors. Autophagy is essential to lung development and homeostasis, as well as the prevention and development of disease. The cellular process involves the collection and removal of unwanted organelles and proteins through lysosomal degradation. In recent years, investigations have addressed the roles of autophagy and selective autophagy in numerous chronic lung diseases. Here, we highlight recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis.

慢性肺病的发展是多种细胞事件的结果，这些事件涉及初始损伤，通常会导致慢性炎症的发展，以及细胞增殖和细胞死亡机制的失调。肺中的多种细胞类型是管理长期暴露于环境、机械和氧化应激源所必需的呼吸和保护/屏障功能的关键。自噬对于肺发育和体内平衡以及疾病的预防和发展至关重要。细胞过程涉及通过溶酶体降解收集和去除不需要的细胞器和蛋白质。近年来，研究已经解决了自噬和选择性自噬在许多慢性肺病中的作用。这里，