Objective. We examined whether prefrontal lobe EEG markers of slower brain rhythms, which are correlated with functional brain aging, can reliably reflect those of other brain lobes, as measured by a multichannel device. Methods. EEG measurements were taken of 112 healthy individuals aged 20 to 69 years in the eyes-closed resting state. A 5-minute measurement was taken at 8 regions (Fp1, Fp2, F3, F4, T3, T4, O1, O2). Indices (median frequency [MDF], peak frequency [PF]) that quantitatively reflect the characteristics of EEG slowing, and traditional commonly used spectral indices (absolute powers as delta, theta, alpha, beta, and relative power as alpha-to-theta ratio [ATR]), were extracted from the EEG signals. For these indices, the differences between the prefrontal lobe and other areas were analyzed and the test-retest reproducibility was investigated. Results. The EEG slowing indicators showed high conformity over all brain lobes and stable reproducibility. On the other hand, the typical EEG spectral indicators delta, theta, alpha, beta, and ATR differed between brain regions. Conclusion. It was found that EEG slowing markers, which were used for assessing the aging or degeneration of brain functions, could be reliably extracted from a prefrontal EEG alone. Significance. These findings suggest that EEG prefrontal markers may reflect markers of other brain regions when a multi-channel device is used. Thus, this method may constitute a low-cost, wearable, wireless, easily accessible, and noninvasive tool for neurological assessment that could be used in the early detection of cognitive decline and in the prevention of dementia.

中文翻译：

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评估闭眼静息状态下脑节律减慢的前额叶脑电图标志物的复测可靠性

客观的。我们检查了与功能性大脑老化相关的较慢脑节律的前额叶脑电图标记是否可以可靠地反映其他脑叶的标记，如通过多通道设备测量的那样。方法。对 112 名 20 至 69 岁处于闭眼休息状态的健康人进行脑电图测量。在 8 个区域（Fp1、Fp2、F3、F4、T3、T4、O1、O2）进行了 5 分钟的测量。定量反映脑电图减慢特征的指数（中频[MDF]、峰值频率[PF]），传统常用的频谱指数（绝对功率为delta、theta、alpha、beta，相对功率为alpha-to-theta比率 [ATR])，是从 EEG 信号中提取的。对于这些指数，分析了前额叶和其他区域之间的差异，并研究了重测再现性。结果。脑电图减速指标显示所有脑叶高度一致，重现性稳定。另一方面，典型的 EEG 频谱指标 delta、theta、alpha、beta 和 ATR 在大脑区域之间有所不同。结论。发现用于评估大脑功能老化或退化的脑电图减慢标志物可以单独从前额叶脑电图中可靠地提取出来。意义。这些发现表明，当使用多通道设备时，脑电图前额叶标志物可能会反映其他大脑区域的标志物。因此，这种方法可能构成一种低成本、可穿戴、无线、易于访问、