Taurine (Tau), an endogenous non-protein and sulfuric-amino acid, is involved in various biological pathways including anti-inflammatory, anti-oxidation, insulin resistance inhibition, and lipid profile improvement. According to some experimental and clinical studies, insulin resistance and excess body weight are associated with reduced serum level of Tau. Therefore, this study was aimed to evaluate Tau supplementation and a diet-induced weight-loss intervention on body composition and some biochemical indices of obese women. Participants were divided randomly into the intervention (standard weight-loss group + cap Tau 3 g/day for 8 weeks, n = 20) and control (standard weight-loss group + cap placebo for 8 weeks, n = 18) groups. To achieve weight loss, all participants received an individualized diet that included a 30% reduction in their total energy intake. Chi-square test was applied to compare categorical variables between two groups at baseline. Paired t test and independent-sample t test were also used to analyze the parametric continuous data within and between the two groups, respectively. Analysis of covariance was run for controlling the confounding variables. At the post-intervention, the mean changes of total cholesterol (p = 0.03), low-density lipoprotein cholesterol (p = 0.03), leptin (p = 0. 006), total adiponectin (p = 0.04), and high sensitivity C-reactive protein (p = 0.03) decreased significantly in Tau group compared with the control group. No significant results were found in the mean changes of high-density lipoprotein cholesterol, anthropometric measurements, glycemic indices, and liver enzymes between the two groups (p > 0.05). The findings showed that Tau supplementation along with a weight-loss diet may be more effective in improving the lipid profile and metabolic risk factors compared with a weight-loss diet alone.

牛磺酸（Tau）是一种内源性非蛋白质和硫酸氨基酸，参与多种生物途径，包括抗炎，抗氧化，抑制胰岛素抵抗和改善脂质分布。根据一些实验和临床研究，胰岛素抵抗和超重与血清Tau含量降低有关。因此，本研究旨在评估补充Tau和饮食诱导的减肥干预对肥胖女性的身体组成和一些生化指标的影响。参与者被随机分为干预（标准减肥组+帽头3g /天，持续8周，Ñ  = 20）和对照（标准减肥组+帽安慰剂，持续8周，Ñ = 18）组。为了减轻体重，所有参与者都接受了个性化饮食，其中包括他们的总能量摄入减少了30％。卡方检验用于比较基线时两组之间的分类变量。配对t检验和独立样本t检验也分别用于分析两组内和两组之间的参数连续数据。进行协方差分析以控制混杂变量。干预后，总胆固醇（p  = 0.03），低密度脂蛋白胆固醇（p  = 0.03），瘦素（p  = 0.006），总脂联素（p  = 0.04）和高敏感性C的平均变化反应蛋白p  = 0.03）与对照组相比，Tau组明显降低。两组之间高密度脂蛋白胆固醇的平均变化，人体测量，血糖指数和肝酶均未发现显着结果（p  > 0.05）。研究结果表明，与单独的减肥饮食相比，Tau补充剂与减肥饮食一起可能在改善脂质状况和代谢危险因素方面更为有效。