Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the “gut-lung axes,” where gut microbiome composition influences the lung’s susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights may further help to develop better intervention strategies for COVID-19 and other diseases caused by respiratory viruses.

中文翻译：

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COVID-19和肠道微生物组：不仅仅是肠道感觉。

由于其在免疫系统的诱导，训练和功能中的基本作用，至关重要的是在临床试验和研究中包括肠道微生物组的表征，旨在扩大我们对2019年冠状病毒病（COVID-19）的了解。了解“肠道-肺轴”，肠道微生物组的成分会影响肺对病毒感染的敏感性，而肺部病毒感染会改变肠道微生物组的成分对促炎性功能障碍的发生，这对于解决COVID-19至关重要，包括疾病进展，重要性既往病情，以及发生并发症的风险。这些见解可能进一步有助于为COVID-19和其他由呼吸道病毒引起的疾病开发更好的干预策略。