In this study, Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) upconversion nanotubes (UCNTs) were synthesised by using Gd(OH)3:Ln3+ (Ln3+ = Yb3+, Er3+) nanotubes as the template. The luminescent and biological properties of Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) UCNTs, along with photodynamic therapy (PDT) applications of the Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 (chlorin e6) nanocomposites, were systematically studied. The resultant UCNTs showed excellent biocompatibility with human retinal pigment cells (ARPE-19) even after a prolonged incubation time of 72 h, and could be used as luminescent probes. Microscopic imaging revealed that the UCNTs existed mainly in cytoplasm. PDT studies on the Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 nanocomposites indicate that the growth of the tumour (cell) could be inhibited dramatically when it was injected (incubated) with Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 nanocomposites under the irradiation of 980 nm laser.

中文翻译：

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基于 Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) 及其衍生物的具有可调荧光特性的上转换纳米管，用于光动力治疗。


本研究以Gd(OH)3:Ln3+(Ln3+=Yb3+,Er3+)纳米管为模板合成了Gd2O2S:Ln3+(Ln3+=Yb3+,Er3+)上转换纳米管(UCNT)。系统研究了 Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) UCNT 的发光和生物学特性，以及 Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 (二氢卟酚 e6) 纳米复合材料的光动力治疗 (PDT) 应用。即使在72小时的长时间孵育后，所得的UCNT仍表现出与人视网膜色素细胞（ARPE-19）优异的生物相容性，并且可以用作发光探针。显微成像显示UCNT主要存在于细胞质中。 Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 纳米复合材料的 PDT 研究表明，注射（孵育）Gd2O2S:8%Yb3+,2%Er3+ UCNT- 可以显着抑制肿瘤（细胞）的生长。 980 nm激光照射下的Ce6纳米复合材料。