Currently, combining stem cells (SCs) with biomaterial scaffolds provides a promising strategy for the future of biomedicine and regenerative medicine (RG). The cells need similar substrates of the extracellular matrix (ECM) for normal tissue development, which signifies the importance of three dimensional (3D) scaffolds to determine cell fate. Herein, the importance and positive contributions of corresponding 3D scaffolds on cell functions, including cell interactions, cell migrations, and nutrient delivery, are presented. Furthermore, the synthesis techniques which are recruited to fabricate the 3D scaffolds are discussed, and the related studies of 3D scaffold for different tissues are also reported in this paper. This review focuses on 3D scaffolds that have been used for tissue engineering purposes and directing stem cell fate as a means of producing replacements for biomedical applications.

目前，将干细胞 (SC) 与生物材料支架相结合，为生物医学和再生医学 (RG) 的未来提供了一种有前景的策略。细胞需要类似的细胞外基质 (ECM) 底物来进行正常组织发育，这表明三维 (3D) 支架对于确定细胞命运的重要性。在此，介绍了相应 3D 支架对细胞功能（包括细胞相互作用、细胞迁移和营养输送）的重要性和积极贡献。此外，本文还讨论了用于制造 3D 支架的合成技术，并报告了不同组织的 3D 支架的相关研究。