The biogeography of the mammalian intestine is remarkable in that a vast microbial consortium exists inside the organism, surrounded by intestinal epithelial cells. The microbiome and the intestinal epithelium have developed a complex network of interactions that maintain intestinal homeostasis. We now recognize that functions of the epithelium are compartmentalized in specific intestinal epithelial cell subtypes. Furthermore, we are beginning to understand the ways in which microbes and their metabolic products impact the specific epithelial subsets. Here, we survey the mechanisms utilized by the microbiome to regulate intestinal epithelial function, and inversely, how different epithelial cell subtypes cooperate in regulating the microbiome.

中文翻译：

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微生物组与上皮细胞相互作用的双向性质。

哺乳动物肠道的生物地理学非常出色，因为在生物体内存在着一个巨大的微生物聚生体，周围被肠道上皮细胞包围。微生物组和肠上皮细胞已经形成了复杂的相互作用网络，可以维持肠道的动态平衡。我们现在认识到上皮的功能在特定的肠上皮细胞亚型中是区隔的。此外，我们开始了解微生物及其代谢产物影响特定上皮亚组的方式。在这里，我们调查了微生物组调节肠道上皮功能的机制，相反，我们考察了不同的上皮细胞亚型如何协同调节微生物组。