We compared autonomic regulation of the heart in Wistar rats with acute exogenous hypoxic and chronic normobaric hypoxia against the background of experimental chronic obstructive pulmonary disease. In animals subjected to normobaric hypoxia, dysfunction of the autonomic regulation of the heart developed; it manifested in a significant limitation of the effects of the parasympathetic and sympathetic nervous systems on the pacemaker activity of the sinoatrial node. Disturbances in autonomic regulation of the heart in acute exogenous hypoxic normobaric hypoxia were characterized by “rigid” heart rhythm and bradycardia in the presence of systolic-diastolic arterial hypotension. Centralization of heart rhythm control did not provide compensation for hemodynamic disturbances. In case of chronic normobaric hypoxia, an increase in arterial hypoxemia was associated with protective “denervation” of the heart against the background of increased activity of the humoral regulation, which manifested in tachycardia, isolated systolic arterial hypertension, and overstrain of regulatory systems.

中文翻译：

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不同起源实验性常压缺氧心脏自主调节的特点

我们在实验性慢性阻塞性肺疾病的背景下比较了急性外源性缺氧和慢性常压缺氧的 Wistar 大鼠心脏的自主调节。在常压缺氧的动物​​中，心脏自主调节功能障碍；它表现为副交感神经和交感神经系统对窦房结起搏器活动的影响显着受限。急性外源性缺氧常压缺氧中心脏自主神经调节紊乱的特征是“刚性”心律和在收缩-舒张动脉低血压的情况下心动过缓。心律控制的集中不能为血流动力学紊乱提供补偿。在慢性常压缺氧的情况下，