Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance patients' microbiomes. Recent evidence has demonstrated that bacterial and viral richness, short chain fatty acid production, bile acid conversion as well as presence of bacterial and fungal pathobionts are associated with therapy efficacy; however, little is known of the influence of host factors such as genetics, medications, and diet. Here, current knowledge on factors associated with fecal transplant efficacy, as well as efforts to transition to other forms of therapy are reviewed.

中文翻译：

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粪便移植物是一种基于微生物组的治疗方法。

受损的微生物组多样性和组成可能发展成为疾病的强大病因，并增加了对感染的易感性。鉴于此，针对微生物组的干预措施发展迅速，健康的供体粪便已成为有益的社区的实际来源，可用来重新平衡患者的微生物群。最近的证据表明，细菌和病毒的丰富性，短链脂肪酸的产生，胆汁酸的转化以及细菌和真菌病原菌的存在与治疗功效相关；然而，人们对诸如遗传，药物和饮食等宿主因素的影响知​​之甚少。在此，对有关与粪便移植功效相关的因素以及过渡到其他治疗形式的努力的最新知识进行了综述。