Applied Physiology, Nutrition, and Metabolism, Ahead of Print.
To examine the utility of changes in cardiorespiratory fitness (CRF) and body composition in response to exercise training in adolescents with obesity beyond simple measures of body weight change. This is a secondary analysis of our previously published randomized trials of aerobic, resistance, and combined training. We included 104 adolescents (body mass index (BMI) ≥85th percentile) who had complete baseline and post-intervention data for CRF, regional body fat, insulin sensitivity, and oral glucose tolerance. Associations between changes in body composition and CRF with cardiometabolic variables were examined adjusted for age, sex, Tanner stage, race, exercise group, and weight loss. At baseline, CRF, visceral fat and liver fat were correlated with insulin sensitivity with and without adjustment for BMI percentile. Training-associated changes in CRF, visceral fat, and liver fat were also correlated with insulin sensitivity changes, but not independent of body weight change. After accounting for body weight change, none of the body composition or CRF were associated with changes in insulin sensitivity, glucose tolerance, systolic blood pressure, or high-density lipoprotein cholesterol. Although CRF and body composition were strong independent correlates of insulin sensitivity at baseline, changes in CRF and visceral fat were not associated with changes in insulin sensitivity after accounting for body weight change. Clinicaltrials.gov registration nos.: NCT00739180, NCT01323088, NCT01938950. Novelty With exercise training, changes in body weight, CRF, visceral fat, and liver fat were correlated with changes in insulin sensitivity. Changes in body composition or CRF generally did not remain significant correlates of changes in insulin sensitivity after adjusting for body weight changes.

中文翻译：

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评估心肺适能、内脏脂肪和肝脏脂肪在预测青少年运动训练后除简单体重变化之外的胰岛素敏感性变化方面的效用。

应用生理学、营养学和代谢，提前出版。
研究心肺适能 (CRF) 和身体成分的变化对肥胖青少年运动训练的影响，而不仅仅是体重变化的简单测量。这是对我们之前发表的有氧训练、阻力训练和联合训练的随机试验的二次分析。我们纳入了 104 名青少年（体重指数 (BMI) ≥ 85%），他们拥有完整的基线和干预后 CRF、局部体脂、胰岛素敏感性和口服葡萄糖耐量数据。根据年龄、性别、Tanner 阶段、种族、运动组和体重减轻，检查了身体成分变化和 CRF 与心脏代谢变量之间的关联。在基线时，CRF、内脏脂肪和肝脏脂肪与胰岛素敏感性相关，无论是否调整 BMI 百分位数。CRF、内脏脂肪和肝脏脂肪的训练相关变化也与胰岛素敏感性变化相关，但与体重变化无关。在考虑体重变化后，身体成分或 CRF 都与胰岛素敏感性、葡萄糖耐量、收缩压或高密度脂蛋白胆固醇的变化无关。尽管 CRF 和身体成分在基线时与胰岛素敏感性有很强的独立相关性，但在考虑体重变化后，CRF 和内脏脂肪的变化与胰岛素敏感性的变化无关。Clinicaltrials.gov 注册号：NCT00739180、NCT01323088、NCT01938950。新颖性 通过运动训练，体重、CRF、内脏脂肪和肝脏脂肪的变化与胰岛素敏感性的变化相关。