Nuclear magnetic resonance (NMR) measurement of ¹J_CC coupling by two‐dimensional (2D) INADEQUATE (incredible natural abundance double quantum transfer experiment), which is a special case of double‐quantum (DQ) spectroscopy that offers unambiguous determination of ¹³C–¹³C spin–spin connectivities through the DQ transitions of the spin system, is especially suited to solving structures rich in quaternary carbons and poor in hydrogen content (Crews rule).

中文翻译：

---

INADEQUATE NMR技术的应用，用于直接追踪天然产物的碳骨架。

二维（2D）INADEQUATE（不可思议的自然丰度双量子转移实验）对¹ J _CC耦合的核磁共振（NMR）测量，这是双量子（DQ）光谱学的特例，它可以确定¹³ C –通过自旋系统的DQ跃迁实现¹³ C自旋-自旋连通性，特别适用于求解富含季碳且氢含量较低的结构（克鲁斯法则）。