Abstract Background In addition to the motor and behavioral symptoms of catatonia, an emerging literature describes co-occurring cognitive dysfunction with catatonia. Memantine is an NMDA receptor antagonist used for some neurocognitive disorders and off-label for catatonia. Objective The objective of this case report is to demonstrate improvement of catatonic symptoms and co-occurring cognitive dysfunction, measured with serial MOCA testing after the administration of memantine. A literature review was also completed examining the effects of memantine on catatonia and co-occurring cognitive dysfunction. Methods We describe the case of a 66 year old female with catatonia who was prescribed memantine. Her cognition was assessed serially utilizing the Montreal Cognitive Assessment. Ten case reports and 3 case series were reviewed examining the treatment effects of memantine on catatonia and co-occurring cognitive dysfunction. Conclusion This case report suggests improvement of both catatonic symptoms and co-occurring cognitive dysfunction with memantine.

中文翻译：

---

美金刚可以改善紧张症和同时发生的认知功能障碍吗？病例报告及文献综述

摘要背景除了紧张症的运动和行为症状外，新出现的文献描述了与紧张症同时发生的认知功能障碍。美金刚是一种 NMDA 受体拮抗剂，用于一些神经认知障碍和紧张症的标签外。目的 本病例报告的目的是证明紧张症状和同时发生的认知功能障碍的改善，通过在给予美金刚后的连续 MOCA 测试来测量。还完成了一篇文献综述，研究了美金刚对紧张症和同时发生的认知功能障碍的影响。方法 我们描述了一名 66 岁的患有紧张症的女性，她被开了美金刚胺。使用蒙特利尔认知评估对她的认知进行了连续评估。回顾了 10 个病例报告和 3 个病例系列，研究了美金刚对紧张症和同时发生的认知功能障碍的治疗效果。结论 该病例报告表明使用美金刚可以改善紧张症症状和同时发生的认知功能障碍。