There is accumulating evidence of dietary impact on several metabolic parameters. Unhealthy diets are estimated to be responsible for about twenty percent of the deaths worldwide. The recommendation is to improve the dietary pattern, aiming to prevent further harm. In this context, we reviewed the benefits and barriers of withdrawing from continuous obesogenic diet intake in the short- and long-term, which were found in rodent models. While dietary modifications demand a re-establishment of the equilibrium, withdrawing was seen as a homeostatic insult, and thus elicited several responses to protect the organism. In the short-term, withdrawals presented stressful and reward de-stimulating responses. The intake of obesogenic diets presented rewarding and stress de-stimulating responses. Whereas withdrawing in the long-term ameliorated several biological functions and histopathologic features, it was not effective in re-establishing food intake and normalizing feeding behaviors nor reward pathways. Altogether, terminating obesogenic diets intake does not immediately extinguish all negative consequences and even elicits brain behavioral and metabolic modifications. These modifications can hinder the maintenance of habits' change and prevent reaching the long-term benefits of diet improvement.

中文翻译：

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退出致肥胖饮食：在啮齿动物模型中短期和长期的收益和障碍。

有越来越多的证据表明饮食对几种代谢参数有影响。据估计，不健康的饮食造成了全世界约20％的死亡。建议是改善饮食习惯，以防止进一步的伤害。在这种情况下，我们回顾了在短期和长期内持续摄入致肥胖饮食的益处和障碍，这些都是在啮齿动物模型中发现的。虽然饮食调整要求重新建立平衡，但戒断被视为是一种稳态的侮辱，因此引发了几种保护有机体的反应。在短期内，提款会带来压力并奖励刺激性的反应。致肥胖饮食的摄入表现出有益和缓解压力的反应。长期撤离可改善一些生物学功能和组织病理学特征，但对重新建立食物摄入量，规范喂养行为或奖励途径无效。总而言之，终止致肥胖饮食的摄入并不能立即消除所有负面影响，甚至不会引起大脑行为和代谢的改变。这些改变会阻碍维持习惯的改变，并无法达到长期改善饮食的益处。